ABSTRACT
AIM: To observe the clinical efficacy of Yishen Yanggan Mingmu formula combined with anti-vascular endothelial growth factor(VEGF)in the treatment of wet age-related macular degeneration(wARMD).METHODS: A total of 58 patients(58 eyes)with wARMD who were treated in Ningbo Eye Hospital from September 2020 to November 2022 were collected. They were divided into two groups according to randomized digital table: 29 patients(29 eyes)for the combination group and the other 29 patients(29 eyes)for the injection group. The injection group was only given intravitreal injection of conbercept; the combination group was orally administrated with Yishen Yanggan Mingmu formula combined with intravitreal injection of conbercept. The best corrected visual acuity(BCVA), central macular thickness(CMT)and the improvement of traditional Chinese medicine(TCM)syndromes after 3mo of treatment were observed and the clinical efficacy was evaluated.RESULTS: After 3mo of treatment, the total improved effective rate of the combination group(76%)was higher than the rate of the injection group(66%). After the treatment, the BCVA of the two groups was both higher than that before treatment(P<0.05), the CMT in both groups was lower than that before the treatment(P<0.05), and the improvement of CMT of the combination group was better than the injection group(-155.93±143.79μm vs. -95.36±56.81μm, P<0.05). After 3mo of treatment, each kinds of TCM syndrome in the combination group were significantly improved compared with those syndromes before the treatment(P<0.001). In the injection group, only blurred vision was improved(P<0.05). After the treatment, the scores of dizziness and insomnia, soreness and weakness of waist and knees, paleness and cold limbs, dry eyes and fatigue in the combination group were significantly lower than the injection group(P<0.001).CONCLUSIONS: The Yishen Yanggan Mingmu formula combined with intravitreal anti-VEGF drug injection is effective in the treatment of wARMD.
ABSTRACT
@#AIM: To compare and observe the image characteristics of polypoidal choroidal vasculopathy(PCV)with frequency domain optical coherence tomography(OCT)andoptical coherence tomography angiographyoptical(OCTA).<p>METHODS: Totally 25 eyes of 25 patients diagnosed with PCV in our hospital from March 2018 to December 2018 were included in the study. All the patients were examined by fluorescein fundus angiography(FFA)and /or indocyanine green angiography(ICGA)and OCT and OCTA were performed at the same time. Their similarities and differences between OCT and OCTA were compared.<p>RESULTS: OCT examination showed 14 eyes with serous and hemorrhagic pigment epithelial detachment(PED)in 25 eyes. OCTA lesions were in dark areas with low signal and 9 eyes showed strong signal points beside. OCTA showed branch vascular network(BVN)of reticular structure in 11 eyes with double layer sign. In 12 eyes with polyps lensions, OCTA showed strong or low signal areas.<p>CONCLUSION: OCTA is more intuitive to BVN in eyes with PCV. Polyps show strong or weak signals. Serous and hemorrhagic PED, OCT and OCTA images all showed low reflection or low singial dark ares,without characteristic. The lesion location and morphology of the two showed similarities, but also differences.